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Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions

[ Vol. 2 , Issue. 3 ]

Author(s):

Gyorgy Keglevich and Alajos Grun   Pages 254 - 263 ( 10 )

Abstract:


In this minireview, the possible utilization of the microwave (MW) technique in solid–liquid (S–L) phase C-alkylations is summarized. In the S–L phase C-alkylation of a series of simple active methylene containing compounds, such as diethyl malonate, ethyl acetoacetate and ethyl cyanoacetate, as well as P=O-containing derivatives, such as tetraethyl methylenebisphosphonate, diethyl cyanomethylphosphonate and diethyl ethoxycarbonylmethylphosphonate, in most of the cases, there is no need to use a phase transfer catalyst, as MW promotes the reaction in itself. Most of the Calkylations was performed under solvent-free conditions. The elimination of the catalyst and solvent from the system means an environmentally friendly (“green”) accomplishment.

Keywords:

C-alkylation, CH-acidic compounds, green chemistry, microwave irradiation, phase transfer catalysis.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.

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