Submit Manuscript  

Article Details

Kabachnik-Fields Reaction Under Green Conditions – A Critical Overview

[ Vol. 2 , Issue. 3 ]


Pawe l Kafarski, Micha l Gorny vel Gorniak and Iga Andrasiak   Pages 218 - 222 ( 5 )


Three-component one-pot Kabachnik-Fields condensation of carbonyl compounds with amines and phosphites is perhaps the most exploited reaction for the preparation of structurally diverse -aminophosphonates. Most of the described protocols might be considered to some extent as green ones with solvent-free and microwave-assisted ones being the most effective.


Phospha-mannich reaction, hydrophosphonylation, green chemistry, catalysis.


Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.

Graphical Abstract:

Read Full-Text article