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A Survey of the Palladium-Catalyzed Hirao Reaction with Emphasis on Green Chemical Aspects

[ Vol. 2 , Issue. 4 ]


Erzsébet Jablonkai and György Keglevich   Pages 379 - 391 ( 13 )


The Pd-catalyzed P–C couplings of aryl, hetaryl and vinyl derivatives and species with a P(O)H function, typically dialkyl phosphites and secondary phosphine oxides giving rise to phosphonates and phosphine oxides are summarized with special emphasis on the green chemical variations. A great variety of reactions are discussed to demonstrate the different conditions and catalyst systems described. environmentally friendly protocols include the use of a phase transfer catalyst and the microwave technique. The best way is to perform the P–C coupling reactions under Pligand- free and solvent-free conditions.


Hirao reaction, P-C coupling, Pd-catalyst, phosphonates, phosphinates, phosphine oxides, P-ligand-free.


Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.

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