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Diverse Roles of Polyethylene Glycol in Organic Transformations: A Review

[ Vol. 4 , Issue. 1 ]


Roona Poddar*   Pages 3 - 24 ( 22 )


Background: The biggest challenge for contemporary organic syntheses is to discover new methods for sustainable, clean and green chemistry. In this context, Poly Ethylene Glycol (PEG) has proven its effectiveness as a potential substitute for reaction media, catalyst or promoter. Owing to its biodegradable and non-toxic nature, it is being actively scrutinized as a green solvent for organic transformation.

Method: Polyethylene glycols are readily utilized under mild conditions and have high selectivity and reactivity with broad range of substrate acceptance to make it better reaction medium for a wide variety of organic transformations. Furthermore, it has been revealed in a number of reports that polyethylene glycol can be efficiently combined with other catalyst from the field of organocatalysis or metal - catalysis resulting in synergistic effect. Moreover, polyethylene glycol is stable under high temperature, microwave irradiation and can act as both liquid and solid phase catalyst.

Conclusion: This study demonstrates as overview on the most recent advances in the current field.


Reaction medium, metal nanoparticles, microwave, solid support, lipase, polyethylene glycol.


Department of Chemistry, University of Delhi, Delhi

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