Manish M. Katiya, Madhukar G. Dhonde* and Jayant M. Gajbhiye Pages 50 - 56 ( 7 )
Background: Solvent-free reaction for the synthesis of thiobarbituric acids (TBAs) by the reaction of 1,3-disubstituted thioureas and malonyl chloride using Amberlyst-15 as a green catalyst has been reported. Recyclability of the catalyst was possible up to five runs without loss of catalytic activity.Conclusion: The simple workup, isolation without column, excellent yields, is main advantages of present protocol.
Thioureas, malonyl chloride, thiobarbituric acid, recyclability, amberlyst-15, plausible mechanism.
Department of Chemistry, Shri Mathuradas Mohota College of Science, Nagpur – 440009, Department of Chemistry, Shri Mathuradas Mohota College of Science, Nagpur – 440009, Organic Chemistry Division, National Chemical Laboratory, Pune-411008