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Solvent-Free Synthesis of Thiobarbituric Acids Using Amberlyst-15 as a Green Catalyst

[ Vol. 4 , Issue. 1 ]

Author(s):

Manish M. Katiya, Madhukar G. Dhonde and Jayant M. Gajbhiye   Pages 50 - 56 ( 7 )

Abstract:


Background: Solvent-free reaction for the synthesis of thiobarbituric acids (TBAs) by the reaction of 1,3-disubstituted thioureas and malonyl chloride using Amberlyst-15 as a green catalyst has been reported. Recyclability of the catalyst was possible up to five runs without loss of catalytic activity.

Conclusion: The simple workup, isolation without column, excellent yields, is main advantages of present protocol.

Keywords:

Thioureas, malonyl chloride, thiobarbituric acid, recyclability, amberlyst-15, plausible mechanism.

Affiliation:

Department of Chemistry, Shri Mathuradas Mohota College of Science, Nagpur – 440009, Department of Chemistry, Shri Mathuradas Mohota College of Science, Nagpur – 440009, Organic Chemistry Division, National Chemical Laboratory, Pune-411008

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