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Green Approaches Towards the Synthesis of Substituted Quinazolines

[ Vol. 4 , Issue. 1 ]


Poornima Devi, Amrita Srivastava, Krishna Srivastava and Abha Bishnoi*   Pages 25 - 37 ( 13 )


Background: Quinazoline refers to the class of condensed ring aromatic organic compounds of the heterocyclic series containing benzene ring fused to pyrimidine nucleus. A wide range of biologically active compounds containing quinazoline ring system have also been synthesized by some of the environmental friendly, so called green methods such as synthesis by means of microwave-irradiation reactions, and multi component reactions (MCR) in water under microwave irradiation etc.

Methods: The present review article describes synthesis of various derivatives of quinazoline by atomefficient, eco-friendly, solvent-free, high yielding, multicomponent green strategies reported in the literature.

Results: These procedures reported in the literature and presented here are compatible with different functional groups.

Conclusion: This review article summarizes the recent advances in the synthesis and biological activity investigations of quinazoline derivatives.


Microwave irradiation, multicomponent reactions (MCR) in water, ultrasonic reactions, quinazolines, green approaches, biological activities.


Department of Chemistry, University of Lucknow, Lucknow 226007, Department of Chemistry, University of Lucknow, Lucknow 226007, Faculty of Chemical Sciences, Shri Ram Swaroop Memorial University, Lucknow 226001, Department of Chemistry, University of Lucknow, Lucknow- 22600

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