Mohammad Nikpassand* and Leila Zare Fekri Pages 103 - 107 ( 5 )
Background: A clean and environmentally benign route to 4H-benzo[h]chromene-3- carbonitriles has been developed via three-component condensation reaction of various benzyl alcohols, malononitrile and 1-naphthol using DBU-hydrobromide-perbromide as an efficient oxidizing reagent at room temperature.
Methodology: The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences.
Conclusion: All of synthesized compounds were characterized by IR, NMR and elemental analyses.
Chromene, benzyl alcohol, multicomponent reaction, 1-Naphthol, malononitrile, TFE.
Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran