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An In Situ Procedure; Grinding Synthesis of 4H-benzo[h]chromene-3- carbonitriles Using DBU-hydrobromide-perbromide

[ Vol. 4 , Issue. 2 ]


Mohammad Nikpassand* and Leila Zare Fekri   Pages 103 - 107 ( 5 )


Background: A clean and environmentally benign route to 4H-benzo[h]chromene-3- carbonitriles has been developed via three-component condensation reaction of various benzyl alcohols, malononitrile and 1-naphthol using DBU-hydrobromide-perbromide as an efficient oxidizing reagent at room temperature.

Methodology: The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences.

Conclusion: All of synthesized compounds were characterized by IR, NMR and elemental analyses.


Chromene, benzyl alcohol, multicomponent reaction, 1-Naphthol, malononitrile, TFE.


Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran

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