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Use of Nano Magnetic Zirconia Phosphoric Acid as an Efficient and Recyclable Catalyst for the Clean Synthesis of Some Important Quinolone Carboxylic Acid Derivatives

[ Vol. 4 , Issue. 3 ]


Ahmad Nakhaei *, Sadaf Farsinejad and Shirin Ramezani   Pages 130 - 136 ( 7 )


Background: In this investigation, nano-Fe3O4@ZrO2-H3PO4 (n-FZPA), as a magnetic catalyst for the preparation of some important fluoroquinolones has been reported.

Methods: These compounds were synthesized by the two-component reaction of piperazine derivatives or (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine with a series of 7-halo-6-fluoroquinolone-3- carboxylic acids upon reflux condition in water as a green solvent.

Results: In the final outcomes, it was found that n-FZPA has high catalytic activity for the preparation of fluoroquinolone derivatives in high yield. Besides, the recyclability of this material has been investigated showing that the n-FZPA could be reused at least three times without any change in its catalytic properties.

Conclusion: This novel and green catalytic procedure provides quick pathway to the target products upon refluxing water with the simple work‐up procedure, and without the use of dangerous organic solvents.


Fluoroquinolones, nano-Fe3O4@ZrO2-H3PO4, recyclability, water, fast synthesis, n-FZPA.


Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad

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