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One-Pot Strategies for the Synthesis of Nitrogen-Containing Heteroaromatics

[ Vol. 5 , Issue. 1 ]

Author(s):

Magne O. Sydnes*   Pages 22 - 39 ( 18 )

Abstract:


Nitrogen-containing heteroaromatics are commonly found in biologically active natural products, pharmaceuticals, agrochemicals, and functional materials. Naturally, this has resulted in such heterocycles being popular synthetic targets for many research groups around the world with numerous methodologies developed for their formation. The preparation of nitrogen-containing heteroaromatics by using various one-pot strategies has lately become more popular due to the increased focus on minimizing waste and cutting back on experimental operations. This review will highlight some of the most recent one-pot strategies used in order to assemble nitrogen containing heteroaromatics with particular emphasis on methodologies leading to the preparation of pyrroles, pyridines, indoles, quinolone, isoquinoline, and imidazo[1,2-a]pyridine.

Keywords:

Nitrogen-containing heteroaromatics, one-pot reactions, multicomponent reactions, pyrrole, pyridine, indole, quinolone, isoquinoline, imidazo[1, 2-a]pyridine.

Affiliation:

Department of Mathematics and Natural Science, Faculty of Science and Technology, University of Stavanger, NO-4036 Stavanger

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