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Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach

[ Vol. 5 , Issue. 2 ]

Author(s):

Satya Karuna Pulakhandam, A Siva Reddy, Naresh Kumar Katari*, Ravi Prakash Reddy Manda and Sreekantha B. Jonnalagadda*   Pages 107 - 112 ( 6 )

Abstract:


Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted thio quinazoline compounds as substrates. All the twelve products were characterized by melting range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.

Keywords:

Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.

Affiliation:

Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh 533 003, Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak, Telangana 502 329, Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak, Telangana 502 329, C-MET, IDA Phase II, Cherlapally HCL (PO), Hyderabad, Telangana 500 057, School of Chemistry & Physics, University of KwaZulu-Natal, P Bag X 54001, Durban 4000



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