Submit Manuscript  

Article Details


Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

[ Vol. 5 , Issue. 2 ]

Author(s):

Srinivas L. Nakkalwar, Shivaji B. Patwari, Mahasim M. Patel and Vivekanand B. Jadhav*   Pages 121 - 126 ( 6 )

Abstract:


An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out. The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation reaction was performed in water, which is an environmentally benign universal solvent having unique properties being clean, efficient, inexpensive, and readily available.

Keywords:

Aromatic aldehydes containing an electron donating groups, hydroxylamine hydrochloride, ethyl acetoacetate, 4- arylidene-3-methylisoxazol-5(4H)-ones, iodine & water.

Affiliation:

Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH), Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH), Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH), Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH)



Read Full-Text article