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Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions

[ Vol. 6 , Issue. 2 ]

Author(s):

Anxhela Akolli, Silvia Moretti , Francesca Mangiavacchi , Bonifacio Monti and Claudio Santi*   Pages 147 - 151 ( 5 )

Abstract:


A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is benign and inexpensive affording good results in very mild conditions allowing to reduce the required amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be conveniently followed by 1H-NMR.

Keywords:

Rutin, arginine, deuterium oxide, NMR, TRIS, solvent.

Affiliation:

Department of Pharmaceutical Sciences, Group of Catalysis and Organic Green Chemistry, University of Perugia, Perugia, Eco Tech, Ponte San Giovanni, Perugia, Department of Pharmaceutical Sciences, Group of Catalysis and Organic Green Chemistry, University of Perugia, Perugia, Department of Pharmaceutical Sciences, Group of Catalysis and Organic Green Chemistry, University of Perugia, Perugia, Department of Pharmaceutical Sciences, Group of Catalysis and Organic Green Chemistry, University of Perugia, Perugia

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