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Green Protocols for the Synthesis of 3,3’-spirooxindoles – 2016- mid 2019

[ Vol. 6 , Issue. 3 ]

Author(s):

Ani Deepthi*, Noble V. Thomas and Vidya Sathi   Pages 210 - 225 ( 16 )

Abstract:


Spirooxindoles, particularly 3,3’-spirooxindoles constitute a privileged structural scaffold owing to the intensive biological activities which they possess. Because of this over the last twenty years, a large number of methods were devised for their synthesis and some of these molecules have entered pre-clinical trials. Of late, methods for spirooxindole synthesis using green protocols have developed rapidly. Reactions based on multicomponent strategies using non-catalytic / biocatalytic pathways and those done in aqueous media have been largely employed for the synthesis of 3,3’- spirooxindoles. This review focusses on the synthesis of 3,3’-spirooxindoles via green protocols and covers the literature from 2016 onwards (2016 - mid 2019); a review on the same topic has appeared in 2016. The green methods discussed here include reactions done in aqueous media, multicomponent strategies, alternate solvents and photocatalysis.

Keywords:

3, 3'-spirooxindoles, multicomponent reactions, spiropyrans, spiropyrrolidines, catalysts, green.

Affiliation:

Department of Chemistry, University of Kerala, Thiruvananthapuram 695581, Kerala, Department of Chemistry, University of Kerala, Thiruvananthapuram 695581, Kerala, Department of Chemistry, University of Kerala, Thiruvananthapuram 695581, Kerala

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