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An Updated Library on the Synthesis of Aziridines

[ Vol. 6 , Issue. 3 ]

Author(s):

Anindita Mukherjee, Nirnita C. Ghosal, Grigory V. Zyryanov, Adinath Majee* and Sougata Santra*   Pages 226 - 241 ( 16 )

Abstract:


Aziridines are highly versatile intermediates in organic synthesis due to their easy access and their susceptibility to ring-opening by facile C-N bond cleavage. They are synthetically very important as they are valuable precursors of amino sugars, β-lactam antibiotics and alkaloids or present in various natural products that exhibit potent biological activities. The synthesis of this moiety from the easily available chemicals is desirable due to its tremendous use in the various branches of chemistry. Here, a short review has been reported on the synthesis of this scaffold employing different strategies under different greener conditions. Various methods have been developed in the presence of green catalysts and solvents.

Keywords:

Aziridines, organic synthesis, green chemistry, olefins, chloramine-T, imine.

Affiliation:

Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., K-2, Yekaterinburg, 620002, Department of Chemistry, University of Calcutta, Sir Rashbehari Shiksha Prangan, 92, A.P.C. Road, Kolkata-700 009, Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., K-2, Yekaterinburg, 620002, Department of Chemistry, Visva-Bharati (A Central University), Santiniketan-731235, Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., K-2, Yekaterinburg, 620002

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