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A Concise Account on Eco-friendly Synthetic Strategies for Pyrazole Heterocycles

[ Vol. 6 , Issue. 3 ]

Author(s):

Pargat Singh and Mahendra Nath*   Pages 198 - 209 ( 12 )

Abstract:


Five membered nitrogen heterocycles are historically known to exhibit diverse therapeutic properties. In particular, the pyrazole analogues have shown a wide range of pharmacological profiles and a number of drugs containing this scaffold approved for the treatment of various ailments and disorders. Hence, a lot of efforts have been made to develop efficient synthetic strategies for the preparation of a variety of pyrazoles in the past several decades. However, this review describes the environmentally benign protocols for the synthesis of substituted and fused pyrazole molecules.

Keywords:

Aromaticity, biological activity, eco-friendly methods, ionic liquids, pyrazoles, pyrano[2, 3-c]pyrazoles.

Affiliation:

Department of Chemistry, Faculty of Science, University of Delhi, Delhi 110 007, Department of Chemistry, Faculty of Science, University of Delhi, Delhi 110 007

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