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DABCO as a Base and an Organocatalyst in Organic Synthesis: A Review


Dinesh K. Jangid*   Pages 1 - 17 ( 17 )


One of the organocatalysts 1,4-diazabicyclo[2.2.2]octane (DABCO) is an excellent solid catalyst in a number of reactions, it is also a good nucleophile and base in numerous reactions for the synthesis of heterocycles. DABCO catalyses many reactions like cycloaddition reactions, coupling reactions, Baylis-Hillman reaction, Henry reaction, ring opening reactions etc. One more advanced feature of these reactions is that they proceed through environmental friendly pathway. DABCO has more advantages than other organic catalysts because it is an inexpensive, non‐toxic base, eco-friendly and highly reactive catalyst for building of organic frameworks, which produces the desired products in excellent yields with high selectivity. Many catalytic applications of DABCO have been reported for the synthesis of organic framework which have been discussed in this review.


1, 4-diazabicyclo[2.2.2]octane (DABCO), organic transformations, catalysis, environmentally friendly


Department of Chemistry, Faculty of Science, University of Rajasthan, JLN Marg, Jaipur, Rajasthan

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