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A General Method for the Synthesis of 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol-3-yl)(aryl)methanes and tris(indol-3-yl)methanes Using Naturally Occurring Mandelic Acid as an Efficient Organo-catalyst in Aqueous Ethanol at Room Temperature

[ Vol. 7 , Issue. 1 ]

Author(s):

Arvind Singh, Gurpreet Kaur, Amninder Kaur, Vivek K. Gupta and Bubun Banerjee*   Pages 128 - 140 ( 13 )

Abstract:


A simple, facile, straightforward and environmentally benign protocol has been developed for the efficient synthesis of pharmaceutically interesting 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol- 3-yl)(aryl)methanes and tris(indol-3-yl)methanes using a catalytic amount of mandelic acid as an efficient, naturally occurring, low-cost, commercially available organo-catalyst in aqueous ethanol at room temperature.

Keywords:

bis(indol-3-yl)(aryl)methanes, 3, 3-bis(indol-3-yl)indolin-2-ones, tris(1H-indol-3-yl)methane, mandelic acid, room temperature, sustainable synthesis.

Affiliation:

Department of Chemistry, Indus International University, V.P.O. Bathu, Distt. Una, Himachal Pradesh-174301, Department of Chemistry, Indus International University, V.P.O. Bathu, Distt. Una, Himachal Pradesh-174301, Department of Chemistry, Indus International University, V.P.O. Bathu, Distt. Una, Himachal Pradesh-174301, Post-Graduate Department of Physics, University of Jammu, Jammu Tawi-180006, Department of Chemistry, Indus International University, V.P.O. Bathu, Distt. Una, Himachal Pradesh-174301

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