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Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination

[ Vol. 8 , Issue. 2 ]

Author(s):

Amjad Khan Pathan, Pravinkumar Patil, Avinash Shinde and Sainath Zangade*   Pages 166 - 173 ( 8 )

Abstract:


Background: Iodination of the organic substrate is an important reaction for the synthesis of pharmacologically active molecules.

Methods: In view of these concerns, we reported a convenient procedure for the synthesis of iodo compounds using iodine and iodic acid in PEG-400. We have reported an eco-friendly procedure for the preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400).

Results: The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines, and heterocyclic compounds was carried out using iodine, iodic acid, and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on the spectral characterization and mixed melting points.

Conclusion: The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.

Keywords:

Iodination, aromatic compounds, iodine, iodic acid, PEG-400, cross-coupling reactions.

Affiliation:

Research Laboratory in Organic Synthesis, Department of Chemistry, N.E.S. Science College, Nanded-431605 (M.S.), Research Laboratory in Organic Synthesis, Department of Chemistry, N.E.S. Science College, Nanded-431605 (M.S.), Research Laboratory in Organic Synthesis, Department of Chemistry, N.E.S. Science College, Nanded-431605 (M.S.), Department of Chemistry, MadhavraoPatil, ACS College, Palam, Dist. Parbhani (M.S.)

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